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Bioinformatics refers to the collection, classification, storage and the scrutiny of biochemical and biological data. It utilizes personal computers especially, as implemented toward molecular genetics and genomics. It is a quickly emerging division of science and is exceedingly interdisciplinary, utilizing strategies and ideas from basic science and linguistics. This paper, initially display a review of the current and next generation sequencing (NGS) technologies and pointed out some problems regarding its data analysis capability. We present the current bioinformatics methods and proficiency of the prediction based data mining algorithms. The fundamental rule that support bioinformatics analysis has been conferred. Based on the estimation of the chief analysis instruments, we have displayed the overview of various data mining algorithms for the assortment of various examination tools applicable in particular research …