Authors
John P Greenwood, David P Ripley, Colin Berry, Gerry P McCann, Sven Plein, Chiara Bucciarelli-Ducci, Erica Dall’Armellina, Abhiram Prasad, Petra Bijsterveld, James R Foley, Kenneth Mangion, Mark Sculpher, Simon Walker, Colin C Everett, David A Cairns, Linda D Sharples, Julia M Brown, CE-MARC 2 Investigators
Publication date
2016/9/13
Journal
Jama
Volume
316
Issue
10
Pages
1051-1060
Publisher
American Medical Association
Description
Importance
Among patients with suspected coronary heart disease (CHD), rates of invasive angiography are considered too high.
Objective
To test the hypothesis that among patients with suspected CHD, cardiovascular magnetic resonance (CMR)–guided care is superior to National Institute for Health and Care Excellence (NICE) guidelines–directed care and myocardial perfusion scintigraphy (MPS)–guided care in reducing unnecessary angiography.
Design, Setting, and Participants
Multicenter, 3-parallel group, randomized clinical trial using a pragmatic comparative effectiveness design. From 6 UK hospitals, 1202 symptomatic patients with suspected CHD and a CHD pretest likelihood of 10% to 90% were recruited. First randomization was November 23, 2012; last 12-month follow-up was March 12, 2016.
Interventions
Patients were randomly assigned (240:481:481) to management according to UK NICE …
Scholar articles
JP Greenwood, DP Ripley, C Berry, GP McCann… - Jama, 2016