Authors
Marianna Fontana, Silvia Pica, Patricia Reant, Amna Abdel-Gadir, Thomas A Treibel, Sanjay M Banypersad, Viviana Maestrini, William Barcella, Stefania Rosmini, Heerajnarain Bulluck, Rabya H Sayed, Ketna Patel, Shameem Mamhood, Chiara Bucciarelli-Ducci, Carol J Whelan, Anna S Herrey, Helen J Lachmann, Ashutosh D Wechalekar, Charlotte H Manisty, Eric B Schelbert, Peter Kellman, Julian D Gillmore, Philip N Hawkins, James C Moon
Publication date
2015/10/20
Journal
Circulation
Volume
132
Issue
16
Pages
1570-1579
Publisher
Lippincott Williams & Wilkins
Description
Background
The prognosis and treatment of the 2 main types of cardiac amyloidosis, immunoglobulin light chain (AL) and transthyretin (ATTR) amyloidosis, are substantially influenced by cardiac involvement. Cardiovascular magnetic resonance with late gadolinium enhancement (LGE) is a reference standard for the diagnosis of cardiac amyloidosis, but its potential for stratifying risk is unknown.
Methods and Results
Two hundred fifty prospectively recruited subjects, 122 patients with ATTR amyloid, 9 asymptomatic mutation carriers, and 119 patients with AL amyloidosis, underwent LGE cardiovascular magnetic resonance. Subjects were followed up for a mean of 24±13 months. LGE was performed with phase-sensitive inversion recovery (PSIR) and without (magnitude only). These were compared with extracellular volume measured with T1 mapping. PSIR was superior to magnitude-only inversion recovery LGE …
Scholar articles
M Fontana, S Pica, P Reant, A Abdel-Gadir, TA Treibel… - Circulation, 2015