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Today, around 54% of the world’s population lives in urban areas. By 2050, this share is expected to go up significantly. As a result, city logistics, which focuses on the efficient and effective transportation of goods in urban areas while taking into account the negative effects on congestion, safety, and environment, is critical to ensuring continued quality of life in cities. We review and discuss a variety of current and anticipated challenges and opportunities of city logistics. We hope this helps shaping an appropriate research agenda and stimulates more researchers to enter this exciting field.