Authors
Juliana da Câmara Rocha, Klinger Antonio da Franca Rodrigues, Patrícia Lima do Nascimento Néris, Larisse Virgolino da Silva, Fernanda Silva Almeida, Viviane Silva Lima, Rephany Fonseca Peixoto, Juliene da Câmara Rocha, Fátima de Lourdes Assunção Araújo de Azevedo, Robson Cavalcanti Veras, Isac Almeida de Medeiros, Wagner André Vieira da Silva, Claudio G Lima-Junior, Mário Luiz Araújo de Almeida Vasconcellos, Ian Porto Gurgel do Amaral, Márcia Rosa de Oliveira, Tatjana de Souza Lima Keesen
Publication date
2019/10
Journal
Parasitology research
Volume
118
Pages
3067-3076
Publisher
Springer Berlin Heidelberg
Description
This study is a report on the anti-Leishmania activity of Morita-Baylis-Hillman (MBH) homodimers adducts against the promastigote and axenic amastigote forms of Leishmania (Leishmania) infantum and Leishmania (Leishmania) amazonensis and on the cytotoxicity of these adducts to human blood cells. Both studied homodimers, MBH 1 and MBH 2, showed activity against the promastigote forms of L. infantum and L. amazonensis, which are responsible for visceral and cutaneous leishmaniasis, respectively. Additionally, the homodimers presented biological activity against the axenic amastigote forms of these two Leishmania species. The adducts exhibited no hemolytic activity to human peripheral blood mononuclear cells or erythrocytes at the tested concentrations and achieved higher selectivity indices than amphotericin B. Evaluation of cell death by apoptosis revealed that the homodimers had better …
Scholar articles
J da Câmara Rocha, KA da Franca Rodrigues… - Parasitology research, 2019