Authors
Eva-Lotta Brakemeier, Alexander Luborzewski, Heidi Danker-Hopfe, Norbert Kathmann, Malek Bajbouj
Publication date
2007/8/1
Journal
Journal of psychiatric research
Volume
41
Issue
5
Pages
395-403
Publisher
Pergamon
Description
Repetitive transcranial magnetic stimulation (rTMS) is a brain stimulation technique which had recently been investigated as a putative antidepressant intervention. However, there is little agreement about clinically useful predictors of rTMS outcome. Therefore, the objective of the present study was to determine whether specific biographical, clinical, and psychopathological parameters are associated with the antidepressant response to rTMS in a large sample of 70 depressive patients. We performed a logistic regression analysis in 70 patients with major depressive disorder treated with rTMS of the left dorsolateral prefrontal cortex testing the predictive value of various domains of the depression syndrome as well as the variables episode duration, degree of treatment resistance, and CORE criteria. Response was defined as a 50% reduction of the initial Hamilton score (HAMD). After two weeks of treatment, 21% of …
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