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Objective —To describe the pharmacokinetics of lidocaine and its active metabolite, monoethylglycinexylidide (MEGX), after IV administration of a single bolus of lidocaine in cats that were awake in phase 1 and anesthetized with isoflurane in phase 2 of the study.

Animals —8 healthy adult cats.

Procedure —During phase 1, cats were administered lidocaine (2 mg/kg, IV) as a bolus injection (time 0). During phase 2, cats were anesthetized with isoflurane and maintained at 0.75 times the minimum alveolar concentration of isoflurane for each specific cat. After a 15-minute equilibration period, lidocaine (2 mg/kg, IV) was administered as a bolus injection to each cat (time 0). In both phases, plasma concentrations of lidocaine and MEGX were measured at various time points by use of liquid chromatography-mass spectrometry …