Authors
Wesley C Warren, R Alan Harris, Marina Haukness, Ian T Fiddes, Shwetha C Murali, Jason Fernandes, Philip C Dishuck, Jessica M Storer, Muthuswamy Raveendran, LaDeana W Hillier, David Porubsky, Yafei Mao, David Gordon, Mitchell R Vollger, Alexandra P Lewis, Katherine M Munson, Elizabeth DeVogelaere, Joel Armstrong, Mark Diekhans, Jerilyn A Walker, Chad Tomlinson, Tina A Graves-Lindsay, Milinn Kremitzki, Sofie R Salama, Peter A Audano, Merly Escalona, Nicholas W Maurer, Francesca Antonacci, Ludovica Mercuri, Flavia AM Maggiolini, Claudia Rita Catacchio, Jason G Underwood, David H O’Connor, Ashley D Sanders, Jan O Korbel, Betsy Ferguson, H Michael Kubisch, Louis Picker, Ned H Kalin, Douglas Rosene, Jon Levine, David H Abbott, Stanton B Gray, Mar M Sanchez, Zsofia A Kovacs-Balint, Joseph W Kemnitz, Sara M Thomasy, Jeffrey A Roberts, Erin L Kinnally, John P Capitanio, JH Pate Skene, Michael Platt, Shelley A Cole, Richard E Green, Mario Ventura, Roger W Wiseman, Benedict Paten, Mark A Batzer, Jeffrey Rogers, Evan E Eichler
Publication date
2020/12/18
Journal
Science
Volume
370
Issue
6523
Pages
eabc6617
Publisher
American Association for the Advancement of Science
Description
INTRODUCTION
The rhesus macaque (Macaca mulatta) is one of the most widely used nonhuman primate (NHP) models for studying human biology and disease. As a representative of the Old World monkey lineage, its genetic sequence is also critical for studies of primate evolution.
RATIONALE
Because of the central role of rhesus macaques in both biomedical research and primate adaptation, we sought to generate a new reference genome for this NHP in which most gaps were closed and most protein-coding genes were annotated. A more comprehensively annotated macaque genome and extensive sequencing of individual macaques from existing research populations enables the characterization of standing genetic variation. Understanding the extent of genetic variation among research populations under phenotypic surveillance will identify new models of human genetic disease and allow for the …
Scholar articles
WC Warren, RA Harris, M Haukness, IT Fiddes… - Science, 2020