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Feline herpesvirus type 1 (FHV‐1) is a common and important cause of ocular surface disease, dermatitis, respiratory disease, and potentially intraocular disease in cats. Many antiviral drugs developed for the treatment of humans infected with herpesviruses have been used to treat cats infected with FHV‐1. Translational use of drugs in this manner ideally requires methodical investigation of their in vitro efficacy against FHV‐1 followed by pharmacokinetic and safety trials in normal cats. Subsequently, placebo‐controlled efficacy studies in experimentally inoculated animals should be performed followed, finally, by carefully designed and monitored clinical trials in client‐owned animals. This review is intended to provide a concise overview of the available literature regarding the efficacy of antiviral drugs and other compounds with proven or putative activity against FHV‐1, as well as a discussion of their safety in cats.