Authors
MD Burkitt, DM Pritchard
Publication date
2006/11
Source
Alimentary pharmacology & therapeutics
Volume
24
Issue
9
Pages
1305-1320
Publisher
Blackwell Publishing Ltd
Description
Summary
Background
Gastric carcinoid tumours are rare, but are increasing in incidence.
Aim
To discuss tumour pathogenesis and outline current approaches to patient management.
Methods
Review of published articles following a Pubmed search.
Results
Although interest in gastric carcinoids has increased since it was recognized that they are associated with achlorhydria, to date there is no definite evidence that humans taking long‐term acid suppressing medication are at increased risk. Type I tumours are associated with autoimmune atrophic gastritis and hypergastrinaemia, type II are associated with Zollinger–Ellison syndrome, multiple endocrine neoplasia‐1 and hypergastrinaemia and sporadic type III carcinoids are gastrin‐independent and carry the worst prognosis. Careful investigation of these patients is required, particularly to identify the tumour type, the source of hypergastrinaemia and the …
Total citations
2007200820092010201120122013201420152016201720182019202020212022202320242915122411131413201710111612673
Scholar articles
MD Burkitt, DM Pritchard - Alimentary pharmacology & therapeutics, 2006