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Due to severe sustainability problems caused by the built environment, calls for adopting circular economy principles in building design, such as flexibility and reversibility, are increasing. However, there is still a lack of quantitative studies on the corresponding environmental benefits in this regard. In the present study, a life cycle assessment of a multi-storey residential reference building is carried out, comparing a flexible, reversible building design using a load-bearing steel structure and wooden ceiling elements to a conventional, monolithic design based on reinforced concrete. The assessment is carried out on a whole building level, including construction, operation, maintenance, and the end-of-life phase. Both building designs show similar results for a regular life cycle of 60 years without major refurbishment (13 and 14.5 kg CO₂-eq/m² per operational year). When longer building lifetimes are considered, the …