Inventors
Thomas J Smith, Paul Ashton, Paul A Pearson
Publication date
1995/1/3
Patent office
US
Patent number
5378475
Application number
07658695
Description
A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir comprising the effective agent; a first coating layer, which is essentially impermeable to the passage of the effective agent; and a second coating layer, which is permeable to the passage of the effective agent. The first coating layer covers at least a portion of the inner core; however, at least a small portion of the inner core is not coated with the first coating layer. The second coating layer essentially completely covers the first coating layer and the uncoated …
Total citations
Scholar articles
TJ Smith, P Ashton, PA Pearson - US Patent 5,378,475, 1995