Authors
Maria Sara de Lima Coutinho Mattera, Fernando Yamamoto Chiba, Flávia Lombardi Lopes, Thaís Verônica Saori Tsosura, Maria Angelica Peres, Victor Gustavo Balera Brito, Sandra Helena Penha de Oliveira, Renato Felipe Pereira, Fernando Marani, Rodrigo Martins Dos Santos, Bianca Elvira Belardi, Gestter Willian Lattari Tessarin, Mariana Lopes Benites, Edilson Ervolino, Joel Claudio Heimann, Doris Hissako Sumida
Publication date
2019/8
Journal
Journal of periodontology
Volume
90
Issue
8
Pages
884-893
Description
Background
Maternal periodontal disease leads to low birth weight (LBW), insulin resistance (IR), increased TNF‐α levels, and alterations in insulin signaling in adult offspring. TNF‐α has been associated with the stimulation of IKKβ/NF‐κB, resulting in the decreased expression of GLUT4. Another mechanism that may be involved in decreasing GLUT4 expression is DNA methylation. This study aimed to evaluate in the adult offspring of rats with periodontal disease: IR, inflammatory pathways, DNA methylation, and expression of GLUT4.
Methods
Female Wistar rats were distributed into control and experimental periodontal disease groups. Seven days after induction of periodontal disease, both groups were mated with healthy male rats. After weaning, male offspring were distributed into control offspring (CN‐o) and periodontal disease offspring (PED‐o) groups. Body weights were measured from 0–75 days of …
Scholar articles
MSLC Mattera, FY Chiba, FL Lopes, TVS Tsosura… - Journal of periodontology, 2019