View article

Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, this phenomenon remains largely unstudied. In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach.

Subjects with COPD (n = 20, GOLD II-III, FEV_1predicted 57 ± 11%, age 69 ± 5) and healthy controls (Healthy, n = 58, FEV_1predicted 112 ± 16%, age 67 ± 4) conducted identical whole-body resistance …