Authors
Maria Inês Schmidt, Bruce B Duncan, A Richey Sharrett, Gunnar Lindberg, Peter J Savage, Steven Offenbacher, Maria Inês Azambuja, Russell P Tracy, Gerardo Heiss
Publication date
1999/5/15
Journal
The Lancet
Volume
353
Issue
9165
Pages
1649-1652
Publisher
Elsevier
Description
Background
Type 2 diabetes mellitus and atherosclerotic cardiovascular disease have common antecedents. Since markers of inflammation predict coronary heart disease and are raised in patients with type 2 diabetes, we investigated whether they predict whether people will develop type 2 diabetes.
Methods
12 330 men and women, aged 45–64 years, were followed up for a mean of 7 years. We analysed the association between different markers of acute inflammation and subsequent diagnosis of diabetes. In a subgroup of 610 individuals selected originally for an unrelated atherosclerosis case-control study, we also investigated diabetes associations with total sialic acid and orosomucoid, haptoglobin, and α1-antitrypsin.
Findings
1335 individuals had a new diagnosis of diabetes. Adjusted odds ratios for developing diabetes for quartile extremes were 1·9 (95% CI 1·6–2·3) for raised white-cell count, 1·3 (1·0–1·5 …
Total citations
Scholar articles
MI Schmidt, BB Duncan, AR Sharrett, G Lindberg… - The Lancet, 1999