Authors
Rebecca D Jackson, Andrea Z LaCroix, Margery Gass, Robert B Wallace, John Robbins, Cora E Lewis, Tamsen Bassford, Shirley AA Beresford, Henry R Black, Patricia Blanchette, Denise E Bonds, Robert L Brunner, Robert G Brzyski, Bette Caan, Jane A Cauley, Rowan T Chlebowski, Steven R Cummings, Iris Granek, Jennifer Hays, Gerardo Heiss, Susan L Hendrix, Barbara V Howard, Judith Hsia, F Allan Hubbell, Karen C Johnson, Howard Judd, Jane Morley Kotchen, Lewis H Kuller, Robert D Langer, Norman L Lasser, Marian C Limacher, Shari Ludlam, JoAnn E Manson, Karen L Margolis, Joan McGowan, Judith K Ockene, Mary Jo O'Sullivan, Lawrence Phillips, Ross L Prentice, Gloria E Sarto, Marcia L Stefanick, Linda Van Horn, Jean Wactawski-Wende, Evelyn Whitlock, Garnet L Anderson, Annlouise R Assaf, David Barad
Publication date
2006/2/16
Journal
New England Journal of Medicine
Volume
354
Issue
7
Pages
669-683
Publisher
Massachusetts Medical Society
Description
Background
The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal.
Methods
We recruited 36,282 postmenopausal women, 50 to 79 years of age, who were already enrolled in a Women's Health Initiative (WHI) clinical trial. We randomly assigned participants to receive 1000 mg of elemental calcium as calcium carbonate with 400 IU of vitamin D3 daily or placebo. Fractures were ascertained for an average follow-up period of 7.0 years. Bone density was measured at three WHI centers.
Results
Hip bone density was 1.06 percent higher in the calcium plus vitamin D group than in the placebo group (P<0.01). Intention-to-treat analysis indicated that participants receiving calcium plus vitamin D supplementation had a hazard ratio of 0.88 for hip fracture (95 percent confidence interval, 0.72 to 1.08), 0.90 for clinical spine …
Total citations
Scholar articles
RD Jackson, AZ LaCroix, M Gass, RB Wallace… - New England Journal of Medicine, 2006