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Recent political and economic events have thrown into question several assumptions about how regional economies work and for whom. For Regional Studies, the result is a wave of policy-relevant empirical research on fundamental issues in our field. The papers in this issue cover topics including the creative class, skills, inequality, embeddedness, innovation and immigration, across a range of industries. This kind of analysis of labour, work and skills is essential for developing new models capable of reintegrating innovation and production into economic development strategies that work for the labour market as a whole, reducing inequality, increasing productivity, and building resilient regional economies.