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The purpose of this study was to investigate and compare the effects of two types of resistance training protocols on the adaptation of skeletal muscle strength in older men. Thirty-seven healthy male subjects (50–64 years) participated in this study. Subjects were assigned to one of three groups: high-intensity (80% 1-RM) resistance training (RT80); low-intensity (20% 1-RM) resistance training with vascular restriction (VR-RT20); and a control group (CON) that performed no exercise. Subjects in both exercise groups performed three upper body (at 80% 1-RM) and two lower body exercises either with (20% 1-RM) or without (80% 1-RM) vascular restriction three times a week for 6 weeks. As expected, the RT80 and VR-RT20 groups had significantly (p < 0.01) greater strength increases in all upper body and leg press exercises compared with CON, however, absolute strength gains for the RT80 and VR-RT20 …