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1. In this study the disposition kinetics and plasma availability of moxifloxacin in broiler chickens after single intravenous (i.v.), intramuscular (i.m.) and oral (p.o.) administrations of 5 mg/kg body weight were investigated.

2. Tissue residue profiles (liver, kidney, lung and muscle) and plasma were also studied after multiple intramuscular and oral administration of 5 mg/kg body weight, once daily for 5 consecutive days.

3. The concentrations of the drug in the plasma and tissues were measured using high-performance liquid chromatography (HPLC) with fluorescence detection on samples collected at frequent intervals after drug administration.

4. Following intravenous injection, plasma concentration–time curves were best described by a two-compartment open model. The decline in plasma drug concentration was bi-exponential with half-lives of (t _1/2α) 0·26 h and (t _1/2β) 2·27 …