Authors
Juan Jiménez-Jáimez, Vicente Alcalde Martínez, Miriam Jiménez Fernández, Francisco Bermúdez Jiménez, Francesca Perin, José Manuel Oyonarte Ramírez, Silvia López Fernández, Inmaculada de la Torre, Rocío García Orta, Mercedes González Molina, Elisa María Cabrerizo, Beatriz Álvarez Abril, Miguel Álvarez, Rosa Macías Ruiz, Concepción Correa, Luis Tercedor
Publication date
2017/10/1
Journal
Revista Española de Cardiología (English Edition)
Volume
70
Issue
10
Pages
808-816
Publisher
Elsevier Doyma
Description
Introduction and objectives
Nonischemic sudden cardiac death (SCD) is predominantly caused by cardiomyopathies and channelopathies. There are many diagnostic tests, including some complex techniques. Our aim was to analyze the diagnostic yield of a systematic diagnostic protocol in a specialized unit.
Methods
The study included 56 families with at least 1 index case of SCD (resuscitated or not). Survivors were studied with electrocardiogram, advanced cardiac imaging, exercise testing, familial study, genetic testing and, in some cases, pharmacological testing. Families with deceased probands were studied using the postmortem findings, familial evaluation, and molecular autopsy with next-generation sequencing (NGS).
Results
A positive diagnosis was obtained in 80.4% of the cases, with no differences between survivors and nonsurvivors (P = .53). Cardiac channelopathies were more prevalent among …
Scholar articles
J Jiménez-Jáimez, VA Martínez, MJ Fernández… - Revista Española de Cardiología (English Edition), 2017