Authors
Péter Szabó, István Scheuring, Tamás Czárán, Eörs Szathmáry
Publication date
2002/11
Journal
Nature
Volume
420
Issue
6913
Pages
340-343
Publisher
Nature Publishing Group
Description
The emergence of functional replicases, acting quickly and with high accuracy, was crucial to the origin of life 1. Although where the first RNA molecules came from is still unknown, it is nevertheless assumed that catalytic RNA enzymes (ribozymes) with replicase function emerged at some early stage of evolution 1. The fidelity of copying is especially important because the mutation load limits the length of replicating templates that can be maintained by natural selection 2. An increase in template length is disadvantageous for a fixed digit copying fidelity, however, longer molecules are expected to be better replicases. An iteration for longer molecules with better replicase function has been suggested 3, 4 and analysed mathematically 5. Here we show that more efficient replicases can spread, provided they are adsorbed to a prebiotic mineral surface. A cellular automaton 6 simulation reveals that copying fidelity …
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