Authors
Rogier Louwen, Deborah Horst-Kreft, AG De Boer, L Van Der Graaf, Gerjo de Knegt, M Hamersma, AP Heikema, AR Timms, BC Jacobs, JA Wagenaar, HP Endtz, J Van der Oost, JM Wells, EES Nieuwenhuis, AHM Van Vliet, PTJ Willemsen, Peter van Baarlen, Alex van Belkum
Publication date
2013/2
Journal
European journal of clinical microbiology & infectious diseases
Volume
32
Pages
207-226
Publisher
Springer-Verlag
Description
Guillain–Barré syndrome (GBS) is a post-infectious disease in which the human peripheral nervous system is affected after infection by specific pathogenic bacteria, including Campylobacter jejuni. GBS is suggested to be provoked by molecular mimicry between sialylated lipooligosaccharide (LOS) structures on the cell envelope of these bacteria and ganglioside epitopes on the human peripheral nerves, resulting in autoimmune-driven nerve destruction. Earlier, the C. jejuni sialyltransferase (Cst-II) was found to be linked to GBS and demonstrated to be involved in the biosynthesis of the ganglioside-like LOS structures. Apart from a role in pathogenicity, we report here that Cst-II-generated ganglioside-like LOS structures confer efficient bacteriophage resistance in C. jejuni. By bioinformatic analysis, it is revealed that the presence of sialyltransferases in C. jejuni and other potential GBS-related pathogens …
Total citations
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Scholar articles
R Louwen, D Horst-Kreft, AG De Boer, L Van Der Graaf… - European journal of clinical microbiology & infectious …, 2013