Authors
Heather J Galipeau, Bruno Lamas, Leticia Hernandez-Galan, Marco Constante, Alexandra V Clarizio, Jennifer Jury, Natalia M Breyner, Alberto Caminero Fernandez, Gaston Rueda, Christina Hayes, Justin L McCarville, Miriam Bermúdez-Brito, Julien Planchais, Joseph A Murray, Philippe Langella, Sonia I Niveloni, Julio C Bai, Linda M Loonen, Jerry Wells, Premysl Bercik, Harry Sokol, Elena F Verdu
Publication date
2020/5/1
Journal
Gastroenterology
Volume
158
Issue
6
Pages
S-217
Publisher
WB Saunders
Description
1121 INTESTINAL STEM CELL NICHE IN PATIENTS WITH CELIAC DISEASE Prasenjit Das, Sudha Battu, Alka Singh, Ashish Chauhan, Vineet Ahuja, Siddhartha Datta Gupta, Govind K. Makharia Introduction Villous atrophy in patients with celiac disease is the result of an imbalance between apoptosis of enterocytes at the apical part and regeneration of enterocytes at crypt stem cells along the crypt villous axis. What happens to crypt stem cell niche (ISC) in patients with CeD is not known. Patients & Methods In this study duodenal mucosal biopsies from 92 treatment naïve patients with CeD, a follow up biopsies after six months of gluten-free diet from 49 of these patients and 37 controls were included and their detailed histological examination was done. These biopsies were subjected to immunohistochemical staining for different components of ISC niche, including LGR5+ crypt basal cells (CBC), BMI 1+ position …
Scholar articles
HJ Galipeau, B Lamas, L Hernandez-Galan… - Gastroenterology, 2020