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This paper presents a novel multi-objective genetic algorithm (MOGA) based on the NSGA-II algorithm, which uses metamodels to determine optimal sampling locations for installing pressure loggers in a water distribution system (WDS) when parameter uncertainty is considered. The new algorithm combines the multi-objective genetic algorithm with adaptive neural networks (MOGA–ANN) to locate pressure loggers. The purpose of pressure logger installation is to collect data for hydraulic model calibration. Sampling design is formulated as a two-objective optimization problem in this study. The objectives are to maximize the calibrated model accuracy and to minimize the number of sampling devices as a surrogate of sampling design cost. Calibrated model accuracy is defined as the average of normalized traces of model prediction covariance matrices, each of which is constructed from a randomly generated …