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This special section analyses the practices and the performativity of intermediaries. Rather than conceiving intermediaries as agents that passively transfer knowledge and objects between the worlds of science, policy and the economy, the focus is on how they mobilise, reframe and structure expertise and policy imperatives. The papers demonstrate that intermediaries come to: collectively explore new worlds and ventures; perform, define and constitute new scientific fields; and actively constitute logics such as scientification or forecasting in the development of techno-logical regulation. In this way, the papers that comprise this special section contribute to a performative understanding of the practices engaged in intermediation that extend and challenge documentary and ideographic modes of analysis that dominate current scholarhip.