Authors
George Thom, Stephan U Dombrowski, Naomi Brosnahan, Yasmin Y Algindan, M Rosario Lopez-Gonzalez, Giles Roditi, Michael EJ Lean, Dalia Malkova
Publication date
2020/4/1
Journal
European journal of clinical nutrition
Volume
74
Issue
4
Pages
622-632
Publisher
Nature Publishing Group UK
Description
Background/objectives
Weight-loss maintenance is challenging, and few succeed in the long term. This study aimed to explain how appetite-related hormones, adaptive thermogenesis, perceived hunger and stress influence weight-loss maintenance.
Subjects/methods
Fifteen adult women (age, 46.3 ± 9.5 years; BMI, 39.4 ± 4.3 kg/m2) participated in a 24-month intervention, which included 3–5 months total diet replacement (825–853 kcal/d). Body weight and composition (Magnetic Resonance Imaging), resting metabolic rate (indirect calorimetry), and fasting plasma concentration of leptin, ghrelin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and growth differentiation factor 15 (GDF-15) were measured at baseline and after weight loss, around 6 months. Perceptions relating to weight-loss maintenance were explored using qualitative interviews.
Results
Mean (SD) changes in body weight (−13.8 ± 6.3 …
Scholar articles
G Thom, SU Dombrowski, N Brosnahan, YY Algindan… - European journal of clinical nutrition, 2020