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Climate change analysis is essential, considering the numerous economic and ecological implications of this critical global environmental issue. This paper analyzes the spatial and temporal trends of mean air temperature in Romania’s most important agricultural area, the south and south-eastern region, between 1961 and 2009. In this respect, multiannual (the entire period) and multidecadal (1961–1990, 1971–2000, 1981–2009) trends were analyzed using the Mann–Kendall test and Sen’s slope method at 23 weather stations, annually, seasonally and for the growing season of the region’s main agricultural crops (maize and wheat). Multiannually, the results showed statistically significant temperature increases, on all temporal scales (maximum rate of 0.06 °C/year recorded in summer, equivalent to a net temperature rise of 2.82 °C), except for the autumn season (cooling without statistical significance …