Authors
Sanne P Smeekens, Aylwin Ng, Vinod Kumar, Melissa D Johnson, Theo S Plantinga, Cleo Van Diemen, Peer Arts, Eugene TP Verwiel, Mark S Gresnigt, Karin Fransen, Suzanne Van Sommeren, Marije Oosting, Shih-Chin Cheng, Leo AB Joosten, Alexander Hoischen, Bart-Jan Kullberg, William K Scott, John R Perfect, Jos WM Van Der Meer, Cisca Wijmenga, Mihai G Netea, Ramnik J Xavier
Publication date
2013/1/8
Journal
Nature communications
Volume
4
Issue
1
Pages
1-10
Publisher
Nature Publishing Group
Description
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here by integrating transcriptional analysis and functional genomics, we identified Candida-specific host defence mechanisms in humans. Candida induced significant expression of genes from the type I interferon pathway in human peripheral blood mononuclear cells. This unexpectedly prominent role of type I interferon pathway in anti-Candida host defence was supported by additional evidence. Polymorphisms in type I interferon genes modulated Candida-induced cytokine production and were correlated with susceptibility to systemic candidiasis. In in vitro experiments, type I interferons skewed Candida-induced inflammation from a Th17 response towards a Th1 response. Patients with chronic mucocutaneous candidiasis displayed defective …
Scholar articles
SP Smeekens, A Ng, V Kumar, MD Johnson… - Nature communications, 2013