Authors
Alessio G Morganti, Mariangela Massaccesi, Giuseppe La Torre, Luciana Caravatta, Adele Piscopo, Rosa Tambaro, Luigi Sofo, Giuseppina Sallustio, Marcello Ingrosso, Gabriella Macchia, Francesco Deodato, Vincenzo Picardi, Edy Ippolito, Numa Cellini, Vincenzo Valentini
Publication date
2010/1
Source
Annals of surgical oncology
Volume
17
Pages
194-205
Publisher
Springer-Verlag
Description
Purpose
The objective of this study was to determine the effect on resection rate and survival of neoadjuvant chemoradiotherapy for primarily unresectable locally advanced pancreatic carcinoma.
Methods
A systematic review of recently published literature was performed. Resection rates and survival data were derived from reports published from 2000 onwards. Only recent studies, based on radiotherapy with standard dose and fractionation, have been analyzed.
Results
Thirteen studies with a total of 510 patients met selection criteria. A resection rate of 8.3–64.2% was reported (median, 26.5%). Of the operated patients, 57.1–100% (median, 87.5%) had R0 tumor resection. Most papers reported occasional pathological complete responses (CR, 3.0–8.8%). When outcome in all patients was considered, median survival …
Total citations
Scholar articles
AG Morganti, M Massaccesi, G La Torre, L Caravatta… - Annals of surgical oncology, 2010