Authors
Enrique M Ostrea Jr, Joel D Hernandez, Dawn M Bielawski, Jack M Kan, Gregorio M Leonardo, Michelle Buda Abela, Michael W Church, John H Hannigan, James J Janisse, Joel W Ager, Robert J Sokol
Publication date
2006/7
Journal
Alcoholism: Clinical and Experimental Research
Volume
30
Issue
7
Pages
1152-1159
Publisher
Blackwell Publishing Inc
Description
Background: Biomarkers of fetal exposure to alcohol are important to establish so that early detection and intervention can be made on these infants to prevent undesirable outcomes. The aim of this study was to analyze long‐chain fatty acid ethyl esters (FAEEs) in meconium as potential biomarkers of fetal alcohol exposure and effect.
Methods: Fatty acid ethyl esters were analyzed in the meconium of 124 singleton infants by positive chemical ionization gas chromatography/mass spectrometry (GC/MS) and correlated to maternal ethanol use.
Results: A total of 124 mother/infant dyads were enrolled in the study: 31 were in the control group and 93 were in the alcohol‐exposed group. The incidence (28% vs 9.7%, p=0.037) of ethyl linoleate detected in meconium was significantly higher in the alcohol‐exposed groups than the control groups. Similarly, when the concentrations of ethyl linoleate in meconium were …
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Scholar articles
EM Ostrea Jr, JD Hernandez, DM Bielawski, JM Kan… - Alcoholism: Clinical and Experimental Research, 2006