Authors
Janice K Kiecolt-Glaser, Timothy J Loving, Jeffrey R Stowell, William B Malarkey, Stanley Lemeshow, Stephanie L Dickinson, Ronald Glaser
Publication date
2005/12/1
Journal
Archives of general psychiatry
Volume
62
Issue
12
Pages
1377-1384
Publisher
American Medical Association
Description
Context
A growing epidemiological literature has suggested that marital discord is a risk factor for morbidity and mortality. In addition, depression and stress are associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging.
Objective
To assess how hostile marital behaviors modulate wound healing, as well as local and systemic proinflammatory cytokine production.
Design and Setting
Couples were admitted twice to a hospital research unit for 24 hours in a crossover trial. Wound healing was assessed daily following research unit discharge.
Participants
Volunteer sample of 42 healthy married couples, aged 22 to 77 years (mean [SD], 37.04 [13.05]), married a mean (SD) of 12.55 (11.01) years.
Interventions
During the first research unit admission, couples had a structured social support interaction, and during the second admission, they discussed a …
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Scholar articles
JK Kiecolt-Glaser, TJ Loving, JR Stowell, WB Malarkey… - Archives of general psychiatry, 2005