Authors
Dong Hyun Sinn, Soo Jin Cho, Seonhye Gu, Donghyeong Seong, Danbee Kang, Hyunkyoung Kim, Byoung-Kee Yi, Seung Woon Paik, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak
Publication date
2016/9/1
Journal
Gastroenterology
Volume
151
Issue
3
Pages
481-488. e1
Publisher
WB Saunders
Description
Background & Aims
Nonalcoholic fatty liver disease (NAFLD) has been associated with subclinical atherosclerosis in cross-sectional studies. We investigated the longitudinal association of NAFLD with the development of subclinical carotid atherosclerosis.
Methods
We performed a retrospective cohort study of 8020 adult men (average age, 49.2 y) without carotid atherosclerosis at baseline who underwent repeated health check-up examinations from January 1, 2005, through December 31, 2013. NAFLD status was diagnosed by ultrasonography and classified into 4 groups based on baseline and follow-up findings: none, developed, regressed, or persistent NAFLD. Subclinical carotid atherosclerosis was measured by ultrasound.
Results
The age-adjusted hazard ratio for subclinical carotid atherosclerosis development comparing participants with persistent NAFLD with those without NAFLD was 1.23 (95 …
Scholar articles
DH Sinn, SJ Cho, S Gu, D Seong, D Kang, H Kim… - Gastroenterology, 2016