Authors
Céline Verstuyft, Mathias Schwab, Elke Schaeffeler, Reinhold Kerb, Ulrich Brinkmann, Patrice Jaillon, Christian Funck-Brentano, Laurent Becquemont
Publication date
2003/4
Journal
European journal of clinical pharmacology
Volume
58
Pages
809-812
Publisher
Springer-Verlag
Description
Background
The effect of MDR1 C3435T single nucleotide polymorphism (SNP) in exon 26 on digoxin pharmacokinetics has recently been challenged.
Objective
To clarify the relationships between MDR1 genetic polymorphisms in exon 26 (C3435T) and 21 (G2677T/A) and digoxin pharmacokinetics.
Materials and methods
MDR1 genotypes for C3435T and G2677T/A SNPs were determined in 32 healthy subjects whose single oral dose digoxin pharmacokinetics had been measured over 48 h.
Results
A significant relationship was observed between C3435T SNP and digoxin AUCs (p<0,05). Homozygous TT subjects had 20% higher digoxin plasma concentrations than CT and CC subjects and a trend for higher 48 h digoxin urinary recoveries (TT>CT …
Total citations
Scholar articles
C Verstuyft, M Schwab, E Schaeffeler, R Kerb… - European journal of clinical pharmacology, 2003