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BackgroundThe results of one randomised control trial testing a psychological rehabilitation programme aimed at information processing strategies showed improvements in cognition post-treatment.AimsTo determine whether there are concomitant brain activation changes as a result of engaging in cognitive remediation therapy (CRT).MethodThree groups (patients receiving control therapyor CRT and a healthy control group) were investigated in a repeated measures design using the two-back test. Functional magnetic resonance imaging (fMRI) data and a broad assessment of executive functioning were completed at baseline and post-treatment. Brain activation changes were identified after accounting for possible task-correlated motion artefact.ResultsfMRI analyses indicate that the control group showed decreased activation butthetwo patient groups showed an increase in activation over time. The patient …