Authors
Patrick Connerty, Alireza Ahadi, Gyorgy Hutvagner
Publication date
2015/12/26
Source
International journal of molecular sciences
Volume
17
Issue
1
Pages
31
Publisher
MDPI
Description
microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.
Scholar articles
P Connerty, A Ahadi, G Hutvagner - International journal of molecular sciences, 2015