Authors
Hassan S Dashti, Samuel E Jones, Andrew R Wood, Jacqueline M Lane, Vincent T Van Hees, Heming Wang, Jessica A Rhodes, Yanwei Song, Krunal Patel, Simon G Anderson, Robin N Beaumont, David A Bechtold, Jack Bowden, Brian E Cade, Marta Garaulet, Simon D Kyle, Max A Little, Andrew S Loudon, Annemarie I Luik, Frank AJL Scheer, Kai Spiegelhalder, Jessica Tyrrell, Daniel J Gottlieb, Henning Tiemeier, David W Ray, Shaun M Purcell, Timothy M Frayling, Susan Redline, Deborah A Lawlor, Martin K Rutter, Michael N Weedon, Richa Saxena
Publication date
2019/3/7
Journal
Nature communications
Volume
10
Issue
1
Pages
1100
Publisher
Nature Publishing Group UK
Description
Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p < 5 × 10−8; 43 loci at p < 6 × 10−9). Replication is observed for PAX8, VRK2, and FBXL12/UBL5/PIN1 loci in the CHARGE study (n = 47,180; p < 6.3 × 10−4), and 55 signals show sign-concordant effects. The 78 loci further associate with accelerometer-derived sleep duration, daytime inactivity, sleep efficiency and number of sleep bouts in secondary analysis (n = 85,499). Loci are enriched for pathways including striatum and subpallium development, mechanosensory response, dopamine binding, synaptic neurotransmission and plasticity, among others. Genetic correlation indicates shared links with …
Scholar articles
HS Dashti, SE Jones, AR Wood, JM Lane… - Nature communications, 2019