Authors
Roberto Antonicelli, Fabiola Olivieri, Massimiliano Bonafè, Luca Cavallone, Liana Spazzafumo, Francesca Marchegiani, Maurizio Cardelli, Andrea Recanatini, Paolo Testarmata, Massimo Boemi, Gianfranco Parati, Claudio Franceschi
Publication date
2005/9/1
Journal
International journal of cardiology
Volume
103
Issue
3
Pages
266-271
Publisher
Elsevier
Description
BACKGROUND
Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are key mediators of inflammation and their increased plasma levels are associated with acute coronary syndrome (ACS). Polymorphisms in the promoter region of IL-6 (−174 G>C) and TNF-α (−308 G>A) demonstrated to affect gene expression were analyzed to test their predictive power for cardiovascular death over one year follow-up in elderly male ACS patients.
METHODS
We assessed the IL-6 −174 G>C polymorphism and TNF-α −308 G>A polymorphism in 139 consecutive elderly male patients affected by an ACS, such as ST-Elevation (STEMI), No ST-Elevation (NSTEMI) Myocardial Infarction and Unstable Angina. The presence of well known risk factors for Coronary Heart Diseases (CHD) were also assessed in all ACS patients. Survival rate was assessed after one year follow-up.
RESULTS
We found that IL-6 −174 G>C …
Total citations
Scholar articles
R Antonicelli, F Olivieri, M Bonafè, L Cavallone… - International journal of cardiology, 2005