Authors
Stefano Savonitto, Claudio Cavallini, A Sonia Petronio, Ernesto Murena, Roberto Antonicelli, Alice Sacco, Giuseppe Steffenino, Francesco Bonechi, Ernesto Mossuti, Antonio Manari, Salvatore Tolaro, Anna Toso, Alessandro Daniotti, Federico Piscione, Nuccia Morici, Bruno M Cesana, M Cristina Jori, Stefano De Servi, Italian Elderly ACS Trial Investigators
Publication date
2012/9
Journal
JACC: Cardiovascular Interventions
Volume
5
Issue
9
Pages
906-916
Publisher
American College of Cardiology Foundation
Description
Objectives
This study sought to determine the risk versus benefit ratio of an early aggressive (EA) approach in elderly patients with non–ST-segment elevation acute coronary syndromes (NSTEACS).
Background
Elderly patients have been scarcely represented in trials comparing treatment strategies in NSTEACS.
Methods
A total of 313 patients ≥75 years of age (mean 82 years) with NSTEACS within 48 h from qualifying symptoms were randomly allocated to an EA strategy (coronary angiography and, when indicated, revascularization within 72 h) or an initially conservative (IC) strategy (angiography and revascularization only for recurrent ischemia). The primary endpoint was the composite of death, myocardial infarction, disabling stroke, and repeat hospital stay for cardiovascular causes or severe bleeding within 1 year.
Results
During admission, 88% of the patients in the EA group underwent angiography (55 …
Total citations
Scholar articles
S Savonitto, C Cavallini, AS Petronio, E Murena… - JACC: Cardiovascular Interventions, 2012