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We begin this essay with reflections on major research themes highlighted by the Karoo Special Issue (KSI). These include concerns over land-use change, long-term monitoring, climate change, governance and the need for more interdisciplinary research. We also identify some of the novel contributions of the KSI around these themes and highlight research issues that require further attention. These include greater focus on the social-ecological impact of large-scale infrastructural developments and wildlife ranching, as well as the need for more longitudinal studies related to contemporary social issues. We conclude by outlining a simple framework for thinking about interdisciplinarity in future research efforts in the Karoo. The first axis relates to the natural science/social science continuum, while the second is concerned with the continuum between basic and applied science. Greater awareness of these two …