Authors
Jörg C Schefold, Jan-Philip Zeden, Christina Fotopoulou, Stephan von Haehling, Rene Pschowski, Dietrich Hasper, Hans-Dieter Volk, Christine Schuett, Petra Reinke
Publication date
2009/6/1
Journal
Nephrology Dialysis Transplantation
Volume
24
Issue
6
Pages
1901-1908
Publisher
Oxford University Press
Description
Background. Tryptophan (Trp) is catabolized by indoleamine 2,3-dioxygenase (IDO). Changes in Trp metabolism and IDO activity in chronic kidney disease (CKD) have not been widely studied, and the impact of haemodialysis is uncertain. Here we investigate Trp catabolism, IDO activity and the role of inflammation in moderate to very severe CKD and haemodialysis.
Methods. Eighty individuals were included in a prospective blinded endpoint analysis. Using tandem mass spectrometry, serum levels of Trp, kynurenine (Kyn), kynurenic-acid (Kyna), quinolinic-acid (Quin), 5-hydroxytryptophan (OH-Trp), serotonin (5-HT), estimated IDO activity and inflammatory markers were assessed in 40 CKD patients (age 57 ± 14 years, 21 male, creatinine 4.5 ± 2.7, n = 17 receiving haemodialysis), and in 40 healthy controls (age 34 ± 9 years, 26 male).
Results. Trp levels were unchanged in CKD …
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Scholar articles
JC Schefold, JP Zeden, C Fotopoulou, S von Haehling… - Nephrology Dialysis Transplantation, 2009