Authors
Marc Lorentzen, Elizabeth Christie, Maiqi Liu, Edward Curry, Ahwan Pandey, Katherine Nixon, Jennifer Ploski, Catriona Dickie, Lydia Kondyliou, James Clark, Iain Mcneish, Jonathan Krell, Christina Fotopoulou, Paula Cunnea
Publication date
2024/3/1
Source
International Journal of Gynecologic Cancer
Volume
34
Issue
Suppl 1
Publisher
BMJ Specialist Journals
Description
Introduction/Background
Extensive genomic instability and heterogeneity are characteristics of ovarian high-grade serous cancer (HGSC). Matching best treatment options for patients is difficult due to diverse resistance mechanisms and paucity of predictive biomarkers. Somatic HR-deficiency (HRD) testing is an approved clinical test to stratify patients for PARP-inhibitor treatment. Here, we investigate the effect of spatial and temporal heterogeneity on HRD status.
Methodology
Patients (n=59) at Hammersmith Hospital (HH) underwent primary cytoreductive surgery for advanced HGSC, with tumour biopsies collected (range 4–15) plus any paired relapse samples (n=11). Tumour DNA was extracted (n=5 tumours per case, plus relapse), genotyping performed for all cases with targeted sequencing (20 HR-related genes) performed for a subset. Multi-site CN data was also accessed from two cohorts (GSE38787 …
Scholar articles
M Lorentzen, E Christie, M Liu, E Curry, A Pandey… - 2024