Authors
Corine M Koopmans, Denise Bijlenga, Henk Groen, Sylvia MC Vijgen, Jan G Aarnoudse, Dick J Bekedam, Paul P van den Berg, Karin de Boer, Jan M Burggraaff, Kitty WM Bloemenkamp, Addy P Drogtrop, Arie Franx, Christianne JM de Groot, Anjoke JM Huisjes, Anneke Kwee, Aren J van Loon, Annemiek Lub, Dimitri NM Papatsonis, Joris AM van der Post, Frans JME Roumen, Hubertina CJ Scheepers, Christine Willekes, Ben WJ Mol, Maria G van Pampus
Publication date
2009/9/19
Journal
The Lancet
Volume
374
Issue
9694
Pages
979-988
Publisher
Elsevier
Description
Background
Robust evidence to direct management of pregnant women with mild hypertensive disease at term is scarce. We investigated whether induction of labour in women with a singleton pregnancy complicated by gestational hypertension or mild pre-eclampsia reduces severe maternal morbidity.
Methods
We undertook a multicentre, parallel, open-label randomised controlled trial in six academic and 32 non-academic hospitals in the Netherlands between October, 2005, and March, 2008. We enrolled patients with a singleton pregnancy at 36–41 weeks' gestation, and who had gestational hypertension or mild pre-eclampsia. Participants were randomly allocated in a 1:1 ratio by block randomisation with a web-based application system to receive either induction of labour or expectant monitoring. Masking of intervention allocation was not possible. The primary outcome was a composite measure of poor …
Total citations
Scholar articles
CM Koopmans, D Bijlenga, H Groen, SMC Vijgen… - The Lancet, 2009
CM Koopmans, D Bijlenga, H Groen, SMC Vijgen… - Obstetrical & Gynecological Survey, 2009