Authors
SL Broer, M Dólleman, BC Opmeer, BC Fauser, BW Mol, FJM Broekmans
Publication date
2011/1/1
Source
Human reproduction update
Volume
17
Issue
1
Pages
46-54
Publisher
Oxford University Press
Description
BACKGROUND
Anti-Mullerian hormone (AMH) is a marker of ovarian reserve status and represents a good predictor of ovarian response to ovarian hyperstimulation. The aim of this study was to assess the accuracy of AMH and antral follicle count (AFC) as predictors of an excessive response in IVF/ICSI treatment.
METHODS
A systematic review and meta-analysis of the existing literature was performed. Studies were included if 2 × 2 tables for the outcome excessive response in IVF patients in relation to AMH/AFC could be constructed. Using a bivariate meta-analytic model, both summary point estimates for sensitivity and specificity were calculated, as well as summary ROC curves. Clinical value was analysed by calculating post-test probabilities of excessive response at optimal cut-off levels, as well as the corresponding abnormal test rates.
RESULTS …
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SL Broer, M Dólleman, BC Opmeer, BC Fauser… - Human reproduction update, 2011