Inventors
Itai Benhar, Nir Osherov, Vladimir Dergachev, Alex Martin Szpilman
Publication date
2018/3/27
Patent office
US
Patent number
9925275
Application number
15657649
Description
Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [1]:
Scholar articles
I Benhar, N Osherov, V Dergachev, AM Szpilman - US Patent 9,925,275, 2018
I Benhar, N Osherov, V Dergachev, AM Szpilman - US Patent 9,750,817, 2017