Authors
Suhas Vasaikar, Chen Huang, Xiaojing Wang, Vladislav A Petyuk, Sara R Savage, Bo Wen, Yongchao Dou, Yun Zhang, Zhiao Shi, Osama A Arshad, Marina A Gritsenko, Lisa J Zimmerman, Jason E McDermott, Therese R Clauss, Ronald J Moore, Rui Zhao, Matthew E Monroe, Yi-Ting Wang, Matthew C Chambers, Robbert JC Slebos, Ken S Lau, Qianxing Mo, Li Ding, Matthew Ellis, Mathangi Thiagarajan, Christopher R Kinsinger, Henry Rodriguez, Richard D Smith, Karin D Rodland, Daniel C Liebler, Tao Liu, Bing Zhang, Akhilesh Pandey, Amanda Paulovich, Andrew Hoofnagle, DR Mani, Daniel W Chan, David F Ransohoff, David Fenyo, David L Tabb, Douglas A Levine, Emily S Boja, Eric Kuhn, Forest M White, Gordon A Whiteley, Heng Zhu, Hui Zhang, Ie-Ming Shih, Jasmin Bavarva, Jeffrey Whiteaker, Karen A Ketchum, Karl R Clauser, Kelly Ruggles, Kimberly Elburn, Linda Hannick, Mark Watson, Mauricio Oberti, Mehdi Mesri, Melinda E Sanders, Melissa Borucki, Michael A Gillette, Michael Snyder, Nathan J Edwards, Negin Vatanian, Paul A Rudnick, Peter B McGarvey, Philip Mertins, R Reid Townsend, Ratna R Thangudu, Robert C Rivers, Samuel H Payne, Sherri R Davies, Shuang Cai, Stephen E Stein, Steven A Carr, Steven J Skates, Subha Madhavan, Tara Hiltke, Xian Chen, Yingming Zhao, Yue Wang, Zhen Zhang
Publication date
2019/5/2
Journal
Cell
Volume
177
Issue
4
Pages
1035-1049. e19
Publisher
Elsevier
Description
We performed the first proteogenomic study on a prospectively collected colon cancer cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, including known and putative new biomarkers, drug targets, and cancer/testis antigens. Proteogenomic integration not only prioritized genomically inferred targets, such as copy-number drivers and mutation-derived neoantigens, but also yielded novel findings. Phosphoproteomics data associated Rb phosphorylation with increased proliferation and decreased apoptosis in colon cancer, which explains why this classical tumor suppressor is amplified in colon tumors and suggests a rationale for targeting Rb phosphorylation in colon cancer. Proteomics identified an association between decreased CD8 T cell infiltration and increased glycolysis in …
Scholar articles
S Vasaikar, C Huang, X Wang, VA Petyuk, SR Savage… - Cell, 2019