Authors
Clara Campàs, Ana M Cosialls, Montserrat Barragán, Daniel Iglesias-Serret, Antonio F Santidrián, Llorenç Coll-Mulet, Mercè de Frias, Alicia Domingo, Gabriel Pons, Joan Gil
Publication date
2006/12/1
Journal
Experimental hematology
Volume
34
Issue
12
Pages
1663-1669
Publisher
Elsevier
Description
OBJECTIVE
Antiapoptotic Bcl-2 is overexpressed in most cases of chronic lymphocytic leukemia (CLL). The inhibition of the antiapoptotic Bcl-2 proteins is an attractive strategy for either restoring normal apoptotic process in cancer cells or making these cells more susceptible to conventional chemotherapy. We studied the effect of Bcl-2 inhibitors on the viability of cells from CLL and other mature B-cell neoplasms.
MATERIALS AND METHODS
We studied the cytotoxic effects of four nonpeptidic cell-permeable Bcl-2 inhibitors (HA14-1, antimycin A, GX15-003, and GX15-070) on B cells from patients with CLL, mantle cell lymphoma (MCL), and splenic marginal zone lymphoma (SMZL). Moreover, we analyzed the effect of these inhibitors in combination with fludarabine or chlorambucil.
RESULTS
HA14-1 induced apoptosis with an EC50 lower than 50 μM in 26 of the 36 CLL samples analyzed. The mean EC50 for …
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Scholar articles
C Campàs, AM Cosialls, M Barragán, D Iglesias-Serret… - Experimental hematology, 2006