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Stromal vascular fraction (SVF) represents an attractive source of adult stem cells and progenitors, holding great promise for numerous cell therapy approaches. In 2017, it was reported that 1524 patients received autologous SVF following the enzymatic digestion of liposuction fat. The treatment was safe and effective and patients showed significant clinical improvement. In a collaborative study, we analyzed SVF obtained from 58 patients having degenerative, inflammatory, autoimmune diseases, and advanced stage cancer.

Flow analysis showed that freshly isolated SVF was very heterogeneous and harbored four major subsets specific to adipose tissue; CD34^high CD45⁻ CD31⁻ CD146⁻ adipose-derived stromal/stem cells (ADSCs), CD34^low CD45⁺ CD206⁺CD31⁻ CD146⁻ hematopoietic stem cell-progenitors (HSC-progenitors …