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Gross motor locomotion is the basis of various sensory motor locomotion. Interventions helping preschoolers develop gross motor skills (GMS) could provide a solid foundation for complex motor skills. This study analyzed a table tennis physical activity program’s influence on preschoolers’ GMS development with 104 preschoolers (experimental group (EG): N = 52, 25 boys, 27 girls; control group (CG): N = 52, 25 boys, 27 girls). The EG conducted table tennis physical activities three times per week for 12 weeks. Preschoolers’ GMSs were assessed using the Test of Gross Motor Development (second edition). After 12 weeks, both the male and female EGs had significantly improved scores for GMS, locomotor subtest, gallop, hop, leap, slide, object control subtest, strike a stationary ball, stationary dribble, catch, overarm throw, and underhand roll (p < 0.05, p < 0.01, p < 0.001). The female EG also showed significant improvement for the run, horizontal jump, and catch in the post-test. Both the male and female EGs significantly outperformed the control group in their post-test scores for GMS, locomotor subtest, object control subtest, strike a stationary ball, overarm throw, and underhand roll (p < 0.05). The female EG also showed significant differences in slide scores (p < 0.05). Therefore, table tennis physical activities can promote preschoolers’ GMS development, especially object control skills. The research results provide an empirical basis for preschoolers’ physical education. Meanwhile, our findings have important implications for preschoolers’ GMS development and table tennis’ popularization in Chinese kindergartens.