Authors
Jordan T Jones, Chelsey Smith, Mara L Becker, Daniel Lovell, CARRA Registry Investigators, N Abel, K Abulaban, A Adams, M Adams, R Agbayani, S Akoghlanian, O Al Ahmed, E Allenspach, R Alperin, M Alpizar, G Amarilyo, D Anastasopoulos, E Anderson, M Andrew, K Ardalan, S Ardoin, E Baker, I Balboni, S Balevic, L Ballenger, S Ballinger, N Balmuri, F Barbar‐Smiley, L Barillas‐Arias, M Basiaga, K Baszis, H Bell‐Brunson, E Beltz, H Benham, S Benseler, W Bernal, T Beukelman, T Bigley, B Binstadt, J Birmingham, C Black, M Blakley, J Bohnsack, J Boland, A Boneparth, S Bowman, E Brooks, A Brown, H Brunner, M Buckley, M Buckley, H Bukulmez, A Bullington, D Bullock, B Cameron, S Canna, L Cannon, S Carpenter, P Carper, V Cartwright, E Cassidy, L Cerracchio, E Chalom, J Chang, A Chang‐Hoftman, V Chauhan, P Chira, Y Chiu, K Chundru, H Clairman, D Co, K Collins, A Confair, H Conlon, R Connor, A Cooper, J Cooper, S Cooper, C Correll, R Corvalan, T Cospito, D Costanzo, R Cron, M Curry, A Dalrymple, A Davis, C Davis, C Davis, T Davis, D De Ranieri, J Dean, F Dedeoglu, M DeGuzman, N Delnay, V Dempsey, E DeSantis, T Dickson, J Dingle, M Dionizovik‐Dimanovski, B Donaldson, E Dorsey, S Dover, J Dowling, J Drew, K Driest, K Drummond, Q Du, K Duarte, D Durkee, E Duverger, J Dvergsten, A Eberhard, M Eckert, K Ede, C Edens, C Edens, Y Edgerly, M Elder, S Fadrhonc, C Failing, D Fair, M Falcon, L Favier, B Feldman, I Ferguson, P Ferguson, B Ferreira, R Ferrucho, K Fields, T Finkel, M Fitzgerald, D Fleck, C Fleming, O Flynn, L Fogel, E Fox, M Fox, L Franco, M Freeman, S Froese, R Fuhlbrigge, J Fuller, N George, T Gergely, K Gerhold, D Gerstbacher, M Gilbert, M Gillispie‐Taylor, E Giverc, I Goh
Publication date
2021/12
Journal
Arthritis Care & Research
Volume
73
Issue
12
Pages
1739-1745
Description
Objective
Down syndrome–associated arthritis (DA) is underrecognized, and current therapies used for juvenile idiopathic arthritis (JIA) appear to be poorly tolerated and less effective in patients with DA. The objective of this study was to characterize clinical manifestations and therapeutic preferences in DA compared to JIA, using the new Childhood Arthritis and Rheumatology Research Alliance (nCARRA) registry.
Methods
In a case–control study, between July 2015 and March 2019, patients with a diagnosis of JIA and Down syndrome (DS) were identified and matched by age, sex, and JIA subtype to patients who have JIA without DS. Collected data included demographic characteristics, disease characteristics, laboratory results, treatment exposure, and outcome measures.
Results
A total of 36 children with DA and 165 with JIA were identified. Most patients presented with polyarticular rheumatoid factor …
Total citations
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