Authors
Sergi Martinez-Ramirez, Octavio Marques Pontes-Neto, Andrew P Dumas, Eitan Auriel, Amy Halpin, Megan Quimby, Mahmut Edip Gurol, Steven M Greenberg, Anand Viswanathan
Publication date
2013/4/23
Journal
Neurology
Volume
80
Issue
17
Pages
1551-1556
Publisher
Lippincott Williams & Wilkins
Description
Objective
To investigate whether the topography of dilated perivascular spaces (DPVS) corresponds with markers of particular small-vessel diseases such as cerebral amyloid angiopathy and hypertensive vasculopathy.
Methods
Patients were recruited from an ongoing single-center prospective longitudinal cohort study of patients evaluated in a memory clinic. All patients underwent structural, high-resolution MRI, and had a clinical assessment performed within 1 year of scan. DPVS were rated in basal ganglia (BG-DPVS) and white matter (WM-DPVS) on T1 sequences, using an established 4-point semiquantitative score. DPVS degree was classified as high (score > 2) or low (score ≤ 2). Independent risk factors for high degree of BG-DPVS and WM-DPVS were investigated.
Results
Eighty-nine patients were included (mean age 72.7 ± 9.9 years, 57% female). High degree of WM-DPVS was more frequent than low …
Scholar articles
S Martinez-Ramirez, OM Pontes-Neto, AP Dumas… - Neurology, 2013